Case study 1

Mr G felt fine when he went to bed at 0130, but his wife awakes at 0345 to find him struggling to get out of bed, unable to move his right arm or leg, and unable to speak. She calls 999 and he arrives at the hospital at 0430

On assessment, his right-sided weakness has now resolved, but he is...

Introduction

Amyloidosis is a disorder of protein folding, where structurally diverse precursor proteins adopt an abnormal but common fibrillar structure, ultimately damaging tissue structure and leading to organ dysfunction. Depending on the dominantly affected organ, a patient may be referred on to a...

Cardiovascular disease (CVD) due to atherosclerosis of the arterial vessel wall and to thrombosis is the foremost cause of premature mortality and morbidity in Europe. The main clinical entities are coronary artery disease (CAD), ischaemic stroke, and peripheral arterial disease (PAD). 

The causes of these...

New therapies modifying the renin angiotensin aldosterone system, the natriuretic peptide system and the sympathetic nervous system have led to considerable improvement in heart failure outcomes in recent years. The long term prognosis of heart failure remains poor, however. Anaemia and iron deficiency are two...

The National Review of Specialist Cardiac Services is due to report later this year. This review was established “to achieve optimal patient outcomes at population level with particular emphasis on safety, quality and sustainability of the services that patients receive by establishing the need for an optimal...