Case study 1

A 65-year-old man presents to the emergency department with sudden onset central chest tightness on a background of exertional chest discomfort and dyspnoea for the past four days

On arrival to hospital he looks unwell, describing central chest tightness for the past hour radiating to left...

Any discussion on lipids generally comes down to one question: “Do I need to start a lipid-lowering therapy to lower my patient’s risk of a cardiovascular event?”

Lifestyle measures are recommended for all patients, and if a secondary cause is identified for elevated lipids that should be addressed first....

Case study 1

Mr G felt fine when he went to bed at 0130, but his wife awakes at 0345 to find him struggling to get out of bed, unable to move his right arm or leg, and unable to speak. She calls 999 and he arrives at the hospital at 0430

On assessment, his right-sided weakness has now resolved, but he is...

Introduction

Amyloidosis is a disorder of protein folding, where structurally diverse precursor proteins adopt an abnormal but common fibrillar structure, ultimately damaging tissue structure and leading to organ dysfunction. Depending on the dominantly affected organ, a patient may be referred on to a...

Cardiovascular disease (CVD) due to atherosclerosis of the arterial vessel wall and to thrombosis is the foremost cause of premature mortality and morbidity in Europe. The main clinical entities are coronary artery disease (CAD), ischaemic stroke, and peripheral arterial disease (PAD). 

The causes of these...